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【熱門】InvivoGen 疫苗佐劑 (Vaccine adjuvants)

【InvivoGen 疫苗佐劑 (Vaccine adjuvants)】
 
疫苗佐劑(Vaccine adjuvants)又稱免疫增強劑或免疫調節劑,通常使用於引發抗體反應的強度不盡理想,或製造疫苗的抗原劑量短缺時。

添加佐劑的好處包括:
(1)促進免疫系統對抗原的交互作用。
(2)誘發人體產生特定的免疫反應:例如刺激單一種類免疫球蛋白的製造,促進毒殺性(cytotoxic)或輔助性T淋巴球(helper T lymphocyte)的增生。
(3)促進免疫反應的品質(包括反應的強度與持續的時間) 。
(4)以較低的抗原劑量、較少的追加劑次引發相同強度的免疫反應。
(5) 降低某些抗原引發的副作用。
(6)可作為疫苗成份的溶劑。


疫苗佐劑不僅可以調節免疫反應的強度,還可以將疫苗的反應類型微調為所需的反應類型。疫苗抗原的免疫反應可分為Th1型和Th2型。Th1型主要產生細胞媒介的免疫反應,對抗細胞內病原體。Th2型是產生中和抗體反應的體液免疫。一般經典佐劑只誘導強效Th2型反應,對於針對病毒免疫的Th1型效果不顯著,所以目前的挑戰是開發有效活化Th1型免疫反應的新型佐劑。隨著天然免疫研究的深入研究,模式識別受體(pattern recognition receptors, PRRs)的天然配體(ligand)或合成活化劑(agonist)逐漸脫穎而出。初期研究發現當與鋁佐劑(alum)或油乳佐劑(emulsion adjuvants)結合使用時,它們能有效引導Th1型免疫反應。

 

 
InvivoGen提供優質疫苗佐劑,包括鋁佐劑(Alum),油乳佐劑(emulsions),弗式佐劑(CFA)和VacciGrade™等級PRR ligands,方便用於疫苗開發研究。

 
Product Description Quantity Catalog
Alum and Emulsions
AddaVax™ Squalene-Oil-in-water - Th1/Th2 response 10 vac-adx-10
Adju-Phos® adjuvant Aluminium phosphate gel - Th2 Response 250 ml vac-phos-250
Alhydrogel® adjuvant 2% Aluminium hydroxide gel (Alum) - Th2 Response 250 ml vac-alu-250
AddaS03™ AS03 -like Vaccine Adjuvant 10 mL vac-as03-10
CFA Complete Freund’s Adjuvant - Th1 response 10 ml 6 x 10 ml vac-cfa-10 vac-cfa-60
IFA Incomplete Freund’s adjuvant - Th2 response 10 ml 6 x 10 ml vac-ifa-10 vac-ifa-60
Quil-A® adjuvant Purified triterpenoid saponin 1 g vac-quil
PRR Ligands
2’3’-c-di-AM(PS)2 (Rp,Rp) VacciGrade™ 2’3’ bisphosphorothioate analog of c-di-AMP - STING agonist 500 µg vac-nacda2r
2’3’-cGAMP VacciGrade™ Cyclic [G(2’,5’)pA(3’,5’)p] - STING agonist 1 mg vac-nacga23
c-di-AMP VacciGrade™ Cyclic diadenylate monophosphate - STING agonist 1 mg vac-nacda
c-di-GMP VacciGrade™ Cyclic diguanylate monophosphate - STING agonist 1 mg vac-nacdg
CL401 VacciGrade™ Chimeric molecule - TLR2 & TLR7 agonist 5 mg vac-c401-5
CL413 VacciGrade™ Chimeric molecule - TLR2 & TLR7 agonist 5 mg vac-c413-5
CL429 VacciGrade™ Chimeric molecule - TLR2 & NOD2 agonist 5 mg vac-c429
Flagellin FliC VacciGrade™ Recombinant flagellin from S. typhimurium - TLR5 agonist 50 µg vac-fla
Imiquimod VacciGrade™ Imidazoquinoline compound -TLR7 agonist 5 mg vac-imq
LPS-EB VacciGrade™ Lipopolysaccharide from E. coli 0111:B4 strain - TLR4 agonist 5 x 106 EU vac-3pelps
MPLA-SM VacciGrade™ Monophosphoryl lipid A from S. minnesota R595 - TLR4 agonist 1 mg vac-mpla
MPLAs Vaccigrade™ Synthetic monophosphoryl lipid A - TLR4 agonist 1 mg vac-mpls
ODN 1585 VacciGrade™ CpG ODN, Class A (murine) - TLR9 agonist 1 mg vac-1585-1
ODN 1826 VacciGrade™ CpG ODN, Class B (murine) - TLR9 agonist 1 mg vac-1826-1
ODN 2006 VacciGrade™ CpG ODN, Class B (human) - TLR9 agonist 1 mg vac-2006-1
ODN 2395 VacciGrade™ CpG ODN, Class C (human/murine) - TLR9 agonist 1 mg vac-2395-1
Pam3CSK4 VacciGrade™ Synthetic triacylated lipoprotein - TLR1/2 agonist 1 mg vac-pms
Poly(I:C) (HMW) VacciGrade™ Polyinosine-polycytidylic acid -TLR3 agonist 10 mg vac-pic
R848 VacciGrade™ Imidazoquinoline compound -TLR7/8 agonist 5 mg vac-r848
TDB VacciGrade™ Synthetic analog of the cord factor - Mincle agonist 2 mg vac-tdb